Resource id #3DrugId:1d00000008resource(4) of type (mysql result) Drug Search

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Drug ID: 1d00000008

Drug Name: Abobotulinum toxin A

Generic Names: Dysport |

Category: Neurotoxins

Legal Status: Non Opioid Prescription only drug


Indication for Mother: Category C:
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Recommended Dose: Intra Muscular- The recommended initial dose is 500 units.

Recommended In: This medication is a neurotoxin, prescribed for cervical dystonia to reduce the severity of abnormal head position and neck pain. It is also used to temporarily smooth wrinkles between the eyebrows. It works by blocking the nerve signals that cause uncontrollable tightening and movement of the muscles.

Directions For Use: It comes as a solution for injection, to be administered by a healthcare provider into the large muscle once in every 3-4 months.

Storage: Store it in refrigerator (2-8C). Do not freeze it.

Dosage Forms: Intra muscular Injection |

Side Effects: Most Common - Weakness, dizziness, drowsiness,difficulty in breathing, talking and swallowing, dry mouth, nausea, diarrhea, stomach pain, loss of appetite, injection site discomfort, loss of bladder control, fatigue, headache, neck pain, musculoskeletal pain, severe skin rash or itching, fast, slow, or uneven heartbeats, ringing in your ears and eye disorders (double, blurred vision and drooping eyelids).

In Case of Overdose: Excessive doses of BOTOX (onabotulinum toxin A) For Injection may be expected to produce neuromuscular weakness with a variety of symptoms.

Symptoms of overdose are likely not to be present immediately following injection. Should accidental injection or oral ingestion occur or overdose be suspected, the person should be medically supervised for several weeks for signs and symptoms of systemic muscular weakness which could be local, or distant from the site of injection.

These patients should be considered for further medical evaluation and appropriate medical therapy immediately instituted, which may include hospitalization.

If the musculature of the oropharynx and esophagus are affected, aspiration may occur which may lead to development of aspiration pneumonia. If the respiratory muscles become paralyzed or sufficiently weakened, intubation and assisted respiration may be necessary until recovery takes place. Supportive care could involve the need for a tracheostomy and/or prolonged mechanical ventilation, in addition to other general supportive care.

In the event of overdose, antitoxin raised against botulinum toxin is available. However, the antitoxin will not reverse any botulinum toxin-induced effects already apparent by the time of antitoxin administration. In the event of suspected or actual cases of botulinum toxin poisoning, please contact your local or state Health Department to process a request for antitoxin.

Avoid If: Caution should be exercised in patients with history of nerve problems, muscle problems (eg, myasthenia gravis, Lambert-Eaton syndrome), seizures, bleeding disorders, diabetes, increased eye pressure, irregular heartbeat, breathing problem, weakness, skin disease, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
It may cause dizziness, vision changes, sensitivity to light, drooping eyelids, or muscle weakness, do not drive a car or operate machinery while taking this medication.

Avoid alcohol consumption.

Rarely patient may develop with increased risk of viral disease or a central nervous system disease called Creutzfeldt-Jakob disease.

Consult with your doctor before starting any new medication.

Drug Interaction: Aminoglycosides and Other Agents Interfering with Neuromuscular Transmission

Co-administration of BOTOX and aminoglycosides or other agents interfering with neuromuscular transmission (e.g., curare-like compounds) should only be performed with caution as the effect of the toxin may be potentiated.

Anticholinergic Drugs

Use of anticholinergic drugs after administration of BOTOX may potentiate systemic anticholinergic effects.

Other Botulinum Neurotoxin Products

The effect of administering different botulinum neurotoxin products at the same time or within several months of each other is unknown. Excessive neuromuscular weakness may be exacerbated by administration of another botulinum toxin prior to the resolution of the effects of a previously administered botulinum toxin.

Muscle Relaxants

Excessive weakness may also be exaggerated by administration of a muscle relaxant before or after administration of BOTOX.

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