Drug ID: 1d00000011
Drug Name: Acebutolol
Generic Names: Sectral | Prent
Legal Status: Non Opioid Prescription only drug
Indication for Mother: Category B
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
Recommended Dose: The recommended initial dose is 200-400mg, twice daily. The maximum allowed dose is 1200mg/day.
Recommended In: This medication is a hydrophilic cardioselective beta-blocker with intrinsic sympathomimetic activity, prescribed for high blood pressure, and arrhythmias (abnormal rhythms of the heart). The medication relaxes blood vessels and improves blood flow.
Directions For Use: It comes as a capsule to take by moth, with or without food.
Storage: Store it at controlled room temperature (20° to 25°C). Keep away from children.
Dosage Forms: Capsule |
Side Effects: Heart - Chest pain, swelling in chest cavity, uneven heartbeats, low blood pressure and heart failure.
Central Nervous System - Depression, fainting, dizziness, fatigue, headache, feeling light-headed, , sleeplessness and abnormal dreams.
Skin - Rash, swelling (especially of the face/tongue/throat) and itching.
Gastrointestinal - Constipation, diarrhea, indigestion, flatulence, nausea, vomiting and abdominal pain.
Genitourinary - Increased urination, dark urine, clay-colored stools, rectal bleeding, painful urination and excessive urinating at night.
Musculoskeletal - Joint/muscle pain.
Respiratory - Cough, difficulty in breathing and inflammation of nose.
Liver - Liver abnormalities, jaundice and increase in liver enzymes.
Special Senses - Abnormal vision, dry eye and eye pain.
Miscellaneous - Development of anti-nuclear antibodies, swelling of ankles or feet, loss of appetite.
In Case of Overdose: No specific information on emergency treatment of overdosage is available for Acebutolol. However, overdosage with other ?-blocking agents has been accompanied by extreme bradycardia, advanced atrioventricular block, intraventricular conduction defects, hypotension, severe congestive heart failure, seizures, and in susceptible patients, bronchospasm and hypoglycemia. Although specific information on the emergency treatment of Acebutolol overdose is not available, on the basis of the pharmacological actions and the observations in treating overdoses with other ?-blockers, the following general measures should be considered:
Empty stomach by emesis or lavage.
Bradycardia: IV atropine (1 to 3 mg in divided doses). If antivagal response is inadequate, administer isoproterenol cautiously since larger than usual doses of isoproterenol may be required.
Persistent hypotension in spite of correction of bradycardia: Administer
vasopressor (e.g., epinephrine, levarterenol, dopamine, or dobutamine) with frequent monitoring of blood pressure and pulse rate.
Bronchospasm: A theophylline derivative, such as aminophylline and/or parenteral ?2-stimulant, such as terbutaline.
Cardiac failure: Digitalize the patient and/or administer a diuretic. It has been reported that glucagon is useful in this situation.
Sectral (acebutolol) is dialyzable.
Avoid If: Caution should be exercised in patients with history of heart, kidney or liver disease, who are taking other medications, asthma or other lung diseases, diseases of the blood vessels, severe allergies, diabetes, thyroid disorder, during pregnancy and breastfeeding.
It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.
Avoid alcohol consumption while taking this drug.
Drug Interaction: Catecholamine-depleting drugs, such as reserpine, may have an additive effect when given with ?-blocking agents. Patients treated with Acebutolol plus catecholamine depletors should, therefore, be observed closely for evidence of marked bradycardia or hypotension which may present as vertigo, syncope/presyncope, or orthostatic changes in blood pressure without compensatory tachycardia. Exaggerated hypertensive responses have been reported from the combined use of ?-adrenergic antagonists and a-adrenergic stimulants, including those contained in proprietary cold remedies and vasoconstrictive nasal drops. Patients receiving ?-blockers should be warned of this potential hazard.
Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by nonsteroidal anti-inflammatory drugs has been reported. No significant interactions with digoxin, hydrochlorothiazide, hydralazine, sulfinpyrazone, oral contraceptives, tolbutamide, or warfarin have been observed.
Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia.