Drug ID: 1d00000031
Drug Name: Adapalene and Benzoyl Peroxide
Generic Names: Epiduo
Legal Status: Non-Opioid,General use.
Indication for Mother: Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Recommended Dose: Apply a thin film to the affected areas of the face and/or trunk once daily after washing.
Recommended In: This combination medication contains retinoid and keratolytic agent, prescribed for acne in patients 9 years of age and older.
Adapalene works by affecting the growth of cells and decreasing swelling and inflammation. Benzoyl peroxide works by reducing the amount of acne-causing bacteria and by causing the skin to dry and peel off.
Directions For Use: It comes as a gel to apply topically as directed by your physician.
Storage: Store at 25°C, excursions permitted to 15° – 30° (59° – 86°F). Protect from light and heat.
Dosage Forms: Gel
Side Effects: Dry skin, feeling of warmth, contact dermatitis, application site burning, irritation, scaling, dryness, itching, and blister.
In Case of Overdose: No information provided.
Avoid If: Caution should be exercised in patients with history of eczema, damaged skin, or a sunburn at the affected area, any allergy, who are taking other medications especially while using other sulfur, resorcinol, or salicylic acid containing medications to treat acne, during pregnancy and breastfeeding.
Caution should be taken if the patient has a history of skin sensitivity to the sun, or spends a lot of time outdoors.
For external use only; avoid contact with eyes, mouth, or nose. Do not apply to the inner lip area, inside the nose/mouth, or on mucus membranes.
Drug Interaction: Concomitant topical acne therapy should be used with caution because a possible cumulative irritancy effect may occur, especially with the use of peeling, desquamating, or abrasive agents. No formal drug-drug interaction studies were conducted with Adapalene and Benzoyl Peroxide.