Resource id #3DrugId:1d00000032resource(4) of type (mysql result) Drug Search

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Drug ID: 1d00000032

Drug Name: Adefovir Dipivoxil

Generic Names: Adesera | Adheb | Adfovir | Hepsera

Category: Antivirals

Legal Status: Non Opioid Prescription only drug

OTC: No

Indication for Mother: Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Recommended Dose: The recommended dose is 10mg/day.

Recommended In: This medication is a reverse transcriptase inhibitor (ntRTI), prescribed for hepatitis B, in patients 12 years of age and older with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease. and herpes simplex virus infection. It slows the growth of HBV by blocking reverse transcriptase, an enzyme that is helpful for viral reproduction. It slows the growth of HBV by blocking reverse transcriptase, an enzyme that is helpful for viral reproduction.

Directions For Use: It comes as a tablet to take by mouth, with or without food.

Storage: Store it in room temperature (25C), and in an airtight container.

Dosage Forms: Tablet

Side Effects: Most Common - Weakness, headache, abdominal pain, diarrhea, nausea, indigestion, flatulence, increased creatinine, and decrease in blood phosphate level.

Gastrointestinal - Inflammation of pancreas.

Muscuskeletal - Muscle pain and softening of bones.

Genitourinary - Kidney failure and Fanconi syndrome.

In Case of Overdose: Doses of adefovir dipivoxil 500 mg daily for 2 weeks and 250 mg daily for 12 weeks have been associated with gastrointestinal side effects. If overdose occurs the patient must be monitored for evidence of toxicity, and standard supportive treatment applied as necessary.

Following a 10 mg single dose of adefovir dipivoxil, a four-hour hemodialysis session removed approximately 35% of the adefovir dose.

Avoid If: Caution should be exercised in patients with history of kidney, liver diseases, abnormal liver function tests, liver transplant, HIV infection, obesity, any allergy, who are taking other medications, elderly, during pregnancy and breastfeeding.

It should not be used in children less than 12 years old.

Monitor kidney and liver functions regularly while taking this medication.
If condition worsens stop the medication immediately.

Should not be used concurrently with tenofovir disoproxil fumarate or tenofovir disoproxil fumarate-containing products.

It does not stop the spread of HBV to others; avoid sexual contact, sharing of needles and injection supplies.

Drug Interaction: Since adefovir is eliminated by the kidney, coadministration of adefovir with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of either adefovir and/or these coadministered drugs.

Patients should be monitored closely for adverse events when adefovir is coadministered with drugs that are excreted renally or with other drugs known to affect renal function.

adefovir should not be administered in combination with VIREAD.



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