Drug ID: 1d00000033
Drug Name: Adenosine
Generic Names: Adenoject | Adenocor | Adnet | Adnet (3 mg) | Carnosine | Carnosine (30 mg) | Adenoject (3 mg) | Adenoject (6mg) | Adenoz | Tachyban | Adenocard
Legal Status: Non Opioid Prescription only drug
Indication for Mother: Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Recommended Dose: Adult- IV- Initial dose: 6 mg given as a rapid intravenous bolus (administered over a 1-2 second period). Repeat Administration: If first dose does not work, 12 mg should be given as a rapid intravenous bolus. This 12 mg dose may be repeated a second time if required.
Child- Initial dose: Give 0.05 to 0.1 mg/kg as a rapid IV bolus. It may be increased upto 0.05 to 0.1 mg/kg if needed.
Recommended In: This medication is an antiarrhythmic agent, prescribed for irregular heart beat. It slows the electrical conduction in the heart.
Directions For Use: It comes as a solution for injection to be administered by a healthcare provider into the vein.
Storage: Store it at controlled room temperature (15º-30ºC), and in an airtight container.
Dosage Forms: Intravenous injection
Side Effects: Heart - Facial flushing, temporary rash on the chest, headache, sweating, palpitations, chest pain and low blood pressure.
Respiratory - Shortness of breath, chest pressure, fast breathing, coughing and head pressure.
Central Nervous System - Lightheadedness, dizziness, tingling in arms, numbness, apprehension, blurred vision, burning sensation, heaviness in arms, neck and back pain.
Gastrointestinal - Nausea, diaphoresis, metallic taste, tightness in throat and pressure in groin.
In Case of Overdose: The half-life of adenosine injection is less than 10 seconds. Thus, adverse effects are generally rapidly self-limiting. Treatment of any prolonged adverse effects should be individualized and be directed toward the specific effect. Methylxanthines, such as caffeine and theophylline, are competitive antagonists of adenosine.
Avoid If: Caution should be exercised in patients with history of lung or breathing problems, gout, any allergy, who are taking other medications, elderly, during pregnancy and breast-feeding.
It may cause dizziness or lightheadedness, do not drive a car or operate machinery while taking this medication.
Avoid drinking large amount of caffeinated beverages.
Monitor electrocardiogram (ECG) regularly while taking this medication.
Drug Interaction: Adenosine injection has been effectively administered in the presence of other cardioactive drugs, such as quinidine, beta-adrenergic blocking agents, calcium channel blocking agents, and angiotensin converting enzyme inhibitors, without any change in the adverse reaction profile. Digoxin and verapamil use may be rarely associated with ventricular fibrillation when combined with Adenosine. Because of the potential for additive or synergistic depressant effects on the SA and AV nodes, however, Adenosine should be used with caution in the presence of these agents. The use of Adenosine in patients receiving digitalis may be rarely associated with ventricular fibrillation.
The effects of adenosine are antagonized by methylxanthines such as caffeine and theophylline. In the presence of these methylxanthines, larger doses of adenosine may be required or adenosine may not be effective. Adenosine effects are potentiated by dipyridamole. Thus, smaller doses of adenosine may be effective in the presence of dipyridamole. Carbamazepine has been reported to increase the degree of heart block produced by other agents. As the primary effect of adenosine is to decrease conduction through the A-V node, higher degrees of heart block may be produced in the presence of carbamazepine.