Resource id #3DrugId:1d00000065resource(4) of type (mysql result) Drug Search

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Drug ID: 1d00000065

Drug Name: Alprostadil

Generic Names: Prostin VR 1 | Alpostin | Prostin VR | Caverject | Edex | Muse

Category: Cholinergic Agents

Legal Status: Non Opioid Prescription only drug


Indication for Mother: Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Recommended Dose: The recommended starting dose is 0.1 micrograms per kilogram of body weight per minute.

Recommended In: This medication is a vasodilator, prescribed for erectile dysfunction (impotence; inability to get or keep an erection) in men. It is also used to improve blood flow in newborn babies with a certain genetic heart condition and who depend on patent ductus arteriosus for survival.

This injection is also sometimes used in combination with other tests to diagnose erectile dysfunction. It relaxes the muscles and blood vessels in the penis to keep enough blood in the penis so that an erection can occur.

Directions For Use: It comes as a powder to be mixed with the liquid provided in the package and injected into the penis and as a urethral suppository (pellet to be placed into the urinary opening of the penis), and newborns injection administered into the vein.

Storage: Store it at room temperature and away from excess heat and moisture.

Dosage Forms: Reconstituted powder for Injection | Suppository | Intravenous injection

Side Effects: Heart- Flushing, slow heart rate, low blood pressure, cardiac arrest, edema. Other rare, but serious, cardiovascular effects include heart failure, second-degree heart block, shock, uncoordinated contraction of the cardiac muscle.

Central Nervous System- Fever, seizures, cerebral bleeding.

Gastrointestinal- Diarrhea.

Genitourinary- Urethral pain, urethral burning, urethral bleeding/spotting, testicular pain, penile pain, prolonged erection, penile fibrosis, injection-site blood clot, penis disorder.

Blood- Pathological activation of blood clotting, bleeding.

Respiratory- Breathing during sleep

Miscellaneous- Cortical proliferation of long bones; sepsis; back pain; pain; pelvic pain; accidental injury.

In Case of Overdose: If intracavernous overdose of alprostadil injection occurs, the patient should be under medical supervision until any systemic effects have resolved and/or until penile detumescence has occurred. Symptomatic treatment of any systemic symptoms would be appropriate.

Avoid If: Monitor blood pressure, blood oxygenation and blood pH continually.

Contraindicated in patients with hypersensitivity,and hyaline membrane disease.

Drug Interaction: No data available.

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