Drug ID: 1d00000066
Drug Name: Alteplase
Generic Names: Actilyse 20 | Actilyse | Cathflo Activase
Legal Status: Non Opioid Prescription only drug
Indication for Mother: Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Recommended Dose: Adult: Acute massive pulmonary embolism- Total dose: 100 mg (not >1.5 mg/kg for patients weighing <65 kg). 10 mg as bolus, followed by infusion of the remainder dose over 2 hour.
Acute stroke: 0.9 mg/kg (not more than 90 mg) IV over 1 hour. The first 10% should be administered in 1 minute.
Heart attack: For patients weighing > 67 kg, 15 mg iv, followed by 50 mg over the next half an hour, and then 35 mg over the next 1 hour. The total dose of 100 mg may also be administered over 3 hours.
Recommended In: This medication is an enzyme (tissue plasminogen activator (tPA)), prescribed for heart attack, stroke, and pulmonary embolism. It helps to break down unwanted blood clots.
Directions For Use: It comes as a solution for injection, to be injected by a healthcare provider into the vein.
Storage: Store it at room temperature (<30°C) or under refrigeration.
Dosage Forms: Intravenous injection
Side Effects: Potentially Fatal- Bleeding in the brain.
Heart - Heart failure, abnormal heart rhythm and heart arrest.
Central Nervous System - Cerebral edema (increased fluid content in the brain).
Miscellaneous- Allergic reactions, nausea, vomiting, low blood pressure and fever.
In Case of Overdose: No data available.
Avoid If: It may lead to serious bleeding, contact your doctor immediately.
Caution should be exercised in children, elderly, pregnant women, and patients with kidney disease.
Monitor for intracranial bleeding and blood pressure in acute stroke.
Contraindicated in patients with recent surgery or trauma, bleeding within the brain, uncontrolled high blood pressure, clotting defects, aneurysm or tumor in brain and active bleeding.
Drug Interaction: In addition to bleeding associated with heparin and vitamin K antagonists, drugs that alter platelet function (such as acetylsalicylic acid, dipyridamole and Abciximab) may increase the risk of bleeding if administered prior to, during, or after alteplase therapy.