Resource id #3DrugId:1d00000071resource(4) of type (mysql result) Drug Search

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Drug ID: 1d00000071

Drug Name: Ambenonium

Generic Names: Mytelase

Category: Cholinesterase Inhibitor

Legal Status: Non Opioid Prescription only drug

OTC: No

Indication for Mother: Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Recommended Dose: The dose is based on patientís condition and response to this medication.

The recommended dose is 5mg to 25mg, three to four times in a day.

Recommended In: This medication is a cholinesterase inhibitor used in the treatment of myasthenia gravis. It inhibits the breakdown of acetylcholine. It prevents breakdown of acetylcholine in the body, which is needed for muscle functions.

Directions For Use: It comes as a capsule to take by mouth, with or without food.

Storage: Store it at room temperature (25įC), and in an airtight container.

Dosage Forms: Tablet

Side Effects: Most Common- Excessive salivation, abdominal cramps, diarrhea, constriction of pupil, urinary urgency, sweating, nausea, increase in bronchial secretions, tears and vomiting.

In Case of Overdose: When the drug produces overstimulation, the clinical picture is one of increasing parasympathomimetic action that is more or less characteristic when not masked by the use of atropine.

Signs and symptoms of overdosage, including cholinergic crises, vary considerably. They are usually manifested by increasing gastrointestinal stimulation with epigastric distress, abdominal cramps, diarrhea and vomiting, excessive salivation, pallor, pollakiuria, cold sweating, urinary urgency, blurring of vision, and eventually fasciculation and paralysis of voluntary muscles, including those of the tongue (thick tongue and difficulty in swallowing), shoulder, neck, and arms. Rarely, generalized malaise and vertigo may occur. Miosis, increase in blood pressure with or without bradycardia, and finally, subjective sensations of internal trembling, and often severe anxiety and panic may complete the picture. A cholinergic crisis is usually differentiated from the weakness and paralysis of myasthenia gravis insufficiently treated by cholinergic drugs by the fact that myasthenic weakness is not accompanied by any of the above signs and symptoms, except the last two subjective ones (anxiety and panic).

In case of overdose, Pralidoxime Chloride may be used. Give other supportive treatment as indicated (artificial respiration, tracheotomy, oxygen, and hospitalization).

Avoid If: Caution should be exercised in patients with history of nerve disorder, asthma, epilepsy, increase in thyroid hormone, Parkinsonís disease, urinary obstruction, heart, lung disease, during pregnancy and breastfeeding.

It is not prescribed in patients who are taking mecamylamine, or any other ganglionic blocking agents; known hypersensitivity.

Drug Interaction: No information available yet.



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