Drug ID: 1d00000075
Drug Name: Amifostine
Generic Names: Naprofos | Cytofos | Amiphos | M Fost | Ethyol | Amfos | Ethyol
Legal Status: Non Opioid Prescription only drug
Indication for Mother: Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Recommended Dose: As a cell protective agent in chemotherapy and radiation.
Adult: Initially, 910 mg/m2 BSA once daily, as an infusion given over 15 minutes, 30 minutes before start of chemotherapy. May reduce to 740 mg/m2 if patient is unable to tolerate the full dose.
For patients receiving cisplatin- <100 mg/m2, a dose of 740 mg/m2 may be given to reduce renal toxicity.
Prophylaxis of dry mouth in patients undergoing radiotherapy for head and neck cancer- Adult: 200 mg/m2 BSA once daily, as an infusion given over 3 minutes, beginning 15-30 minutes before radiotherapy.
Recommended In: This medication is a cytoprotective agent, prescribed for preventing kidney damage due to chemotherapy and reducing the mouth dryness due to radiation therapy.
Directions For Use: This medication available in the form of injection, administered by the healthcare providers.
Storage: Intravenous: Vials containing lyophilized powder: Store at 20-25°C.
Reconstituted solution (500 mg/10 mL): Chemically stable for up to 5 hr at room temperature (about 25°C) or up to 24 hr under refrigeration (2-8°C).
Dosage Forms: Reconstituted powder for injection | Intravenous injection
Side Effects: Heart-Low blood pressure during infusion, fall in pulse pressure.
Central Nervous System- Transient and reversible loss of consciousness rarely, dizziness, drowsiness.
Miscellaneous- Flushing, feeling of warmth, chills, sneezing, cough and skin rashes.
In Case of Overdose: The most likely symptom of overdosage is hypotension, which should be managed by infusion of normal saline and other supportive measures, as clinically indicated.
Avoid If: Caution needed for pregnant women and breast feeding.
Patients should drink water adequately to avoid dehydration.
Prolonged infusion causes greater side effects.
Stop antihypertensive drugs one day before infusion.
Take antiemetics (drug against vomiting and vomiting sensation) before infusion especially if the treatment causes vomiting.
Monitor blood pressure regularly, at least before and immediately after infusion.
Contraindicated in patients with low BP, dehydration, patients with kidney or liver disease, children and elderly >70 years, and hypersensitivity.
Drug Interaction: Special consideration should be given to the administration of amifostine in patients receiving antihypertensive medications or other drugs that could cause or potentiate hypotension.