Resource id #3DrugId:1d00000079resource(4) of type (mysql result) Drug Search

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Drug ID: 1d00000079

Drug Name: Aminoglutethimide

Generic Names: Cytadren

Category: Miscellaneous Endocrine Agents

Legal Status: Non Opioid Prescription only drug


Indication for Mother: Category D
There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Recommended Dose: Adult- Initial- The recommended dose is 250 mg four times daily, preferably at 6-hour intervals.

Recommended In: This medication is an adrenal steroid inhibitor, prescribed for Cushing syndrome. It blocks the hormones secretion in the body.

Directions For Use: It comes as a tablet to take by mouth, with or without food.

Storage: Store it at room temperature.

Dosage Forms: Tablet

Side Effects: Most Frequent - Drowsiness, skin rash, nausea, loss of appetite, and dizziness.

Central Nervous System - Headache.

Heart - Low blood pressure and fast heart rate.

Gastrointestinal - Vomiting.

Skin - Itching and hives.

Miscellaneous - Fever, muscle pain and lung inflammation.

In Case of Overdose: An acute overdose with Cytadren (aminoglutethimide) may reduce the production of steroids in the adrenal cortex to a degree that is clinically relevant. The following manifestations may be expected:

Respiratory depression, hypoventilation, Hypotension, hypovolemic shock due to dehydration, Somnolence, lethargy, coma, ataxia, dizziness, fatigue (Extreme weakness has been reported with divided doses of 3 g daily.), Nausea, vomiting, Loss of sodium and water, Hyponatremia, hypochloremia, hyperkalemia, hypoglycemia.

Symptomatic treatment of overdosage is recommended.

Since aminoglutethimide and glutethimide are chemically related, measures that have been used in successfully removing glutethimide from the body might be useful in removing aminoglutethimide.

Gastric lavage and unspecified supportive treatment have been employed.

Avoid If: Caution should be exercised in patients with history of blood disease porphyria, infection, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.

It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.

Avoid alcohol consumption.

Monitor liver function, thyroid levels, complete blood cell counts, and electrolyte levels regularly while taking this medication.

Drug Interaction: Cytadren (aminoglutethimide) accelerates the metabolism of dexamethasone; therefore, if glucocorticoid replacement is needed, hydrocortisone should be prescribed.

Aminoglutethimide diminishes the effect of coumarin and warfarin.

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