Resource id #3DrugId:1d00000088resource(4) of type (mysql result) Drug Search

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Drug ID: 1d00000088

Drug Name: Amlodipine

Generic Names: Samstar | Amanat (5mg) | Myamlo | Mecard (2.5 mg) | Amnorm | Amlovate | Ampin | Calchek (2.5mg) | Amlostat -5 | Starcad | Myodipine (5 mg) | Carvasc | Ampine | Stamlo (2.5 mg) | Amlopin Plus FC | Todpid | Amlosafe (2.5mg) | Mecard (5 mg) | Axcard | Amlovas (2.5 mg) | Myodipine | Medopin | Odipine (10 mg) | Amlica | Alip -AM | Klodip (2.5mg) | Console -ED (10 mg) | Cardpin -S (2.5 mg) | Topdip (5 mg) | Amlogard (5mg) | Norvasc | Amvaz | Aforbes | Aken | Amcard | Amlod | Amdipin | Amlodine | Amlodipine 5 | Amlopine | Amlostin | Amlovasc | Istin | Amlosun | Lopin | Nelod | Perivasc | Nordip

Category: Calcium Channel Blockers

Legal Status: Non opioid prescription only


Indication for Mother: Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Recommended Dose: Adults- Oral- The usual initial dose is 5 mg once daily with a maximum dose of 10 mg once daily.

Children- 6 to 17 years- The effective dose is 2.5 mg to 5 mg once daily.

Recommended In: This medication is a calcium channel blocker, prescribed for high blood pressure and chest pain. It widens blood vessels and improves blood flow by not making the heart pump harder.

Directions For Use: It comes as a tablet to take by mouth, with or without food.

Storage: Store it at room temperature and in an airtight container.

Dosage Forms: Tablet

Side Effects: Most Common - Dizziness, palpitations, flushing and fluid retention.

Heart - Abnormal heart rhythm, slow heart rate, chest pain, low blood pressure, poor blood circulation, fainting, fast heart rate and inflammation of blood vessels.

Central Nervous System - Sensory loss, nerve disease, tingling, tremor, unsteadiness, sexual dysfunction (male1 and female), sleepless, nervousness, depression, abnormal dreams, anxiety and depersonalization.

Gastrointestinal - Loss of appetite, constipation, indigestion, difficulty in swallowing, diarrhea, flatulence, inflammation of pancreas, vomiting and gum swelling.

General - Allergic reactions, shock, weakness, back pain, hot flushes, uneasiness, pain, rigors, increased sweating, weight gain and weight loss.

Musculoskeletal - Joint pain, muscle cramps and muscle pain.

Respiratory - Difficulty in breathing and nose bleed.

Skin - Redness of the skin, itching, increased sweating and rash.

Eye and ENT - Abnormal vision, eye inflammation, blurred/double vision, eye pain and ringing in the ear.

Genitourinary - Urinary frequency and night time urination.

Metabolic - Dry mouth, increased sugar level and thirst.

Blood - Bruising, decrease in white blood cells and platelets.

In Case of Overdose: Overdosage might be expected to cause excessive peripheral vasodilation with marked hypotension and possibly a reflex tachycardia. In humans, experience with intentional overdosage of Amlodipine is limited.

If massive overdose should occur, initiate active cardiac and respiratory monitoring. Frequent blood pressure measurements are essential. Should hypotension occur, provide cardiovascular support including elevation of the extremities and the judicious administration of fluids. If hypotension remains unresponsive to these conservative measures, consider administration of vasopressors (such as phenylephrine) with attention to circulating volume and urine output. As Amlodipine is highly protein bound, hemodialysis is not likely to be of benefit.

Avoid If: Caution should be exercised in patients with history of heart failure or liver disease, any allergy, who are taking other medications, elderly, during pregnancy and breastfeeding.

It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.

Avoid alcohol consumption.

It should not be used in children less than 6 years old.

Drug Interaction: CYP3A4 Inhibitors

Co-administration of a 180 mg daily dose of diltiazem with 5 mg amlodipine in elderly hypertensive patients resulted in a 60% increase in amlodipine systemic exposure. strong inhibitors of CYP3A4 (e.g., ketoconazole, itraconazole, ritonavir) may increase the plasma concentrations of amlodipine to a greater extent. Monitor for symptoms of hypotension and edema when amlodipine is co-administered with CYP3A4 inhibitors.

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