Resource id #3DrugId:1d00000095resource(4) of type (mysql result) Drug Search

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Drug ID: 1d00000095

Drug Name: Amoxapine

Generic Names: Amolife Tab | Demolox Tab | Oxamine Tab | Asendin.

Category: Psychotherapeutics

Legal Status: Non Opioid Prescription only drug


Indication for Mother: Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Recommended Dose: Adult- Initial- The recommended dose is 50 mg two or three times daily.
It may be increased up to 100 mg 3 times/day.

Recommended In: This medication is a tricyclic antidepressant, prescribed for depression. It increases the amount of certain natural substances in the brain that are needed to maintain mental balance.

Directions For Use: It comes as a tablet to take by mouth, with or without food.

Storage: Keep this medication in a tightly closed container and out of reach of children.

Dosage Forms: Tablet

Side Effects: Most Frequent - Drowsiness, dry mouth, constipation and blurred vision.

Central Nervous System - Anxiety, sleeplessness, restlessness, nervousness, palpitations, tremors, confusion, excitement, nightmares, incoordination and alterations in EEG patterns.

Allergic - Swelling and skin rash.

Endocrine - Elevation of prolactin levels.

Gastrointestinal - Nausea.

Miscellaneous - Dizziness, headache, fatigue, weakness, excessive appetite and increased perspiration.

In Case of Overdose: Toxic manifestations of amoxapine overdosage differ significantly from those of other tricyclic antidepressants. Serious cardiovascular effects are seldom if ever observed. However, CNS effects - particularly grand mal convulsions - occur frequently, and treatment should be directed primarily toward prevention or control of seizures. Status epilepticus may develop and constitutes a neurologic emergency. Coma and acidosis are other serious complications of substantial amoxapine overdosage in some cases. Fatal overdoses with amoxapine have occurred.

Renal failure may develop two to five days after toxic overdosage in patients who may appear otherwise recovered. Acute tubular necrosis with rhabdomyolysis and myoglobinuria is the most common renal complication in such cases. This reaction probably occurs in less than 5% of overdose cases, and typically in those who have experienced multiple seizures.

Avoid If: Caution should be exercised in patients with history of heart problems, epilepsy, seizures, overactive thyroid, increased eye pressure, blood disorder, suicidal thoughts, enlarged prostate, urination problem, any allergy, who are taking other medications, elderly, during pregnancy and breastfeeding.

It may cause drowsiness, dizziness, blurred vision or lightheadedness. Do not drive a car or operate machinery and get up slowly from bed while taking this medication.

Avoid alcohol consumption.

Patient may develop with increased risk of neuroleptic malignant syndrome (NMS) with the following symptoms: fever, muscle tightness, confusion, abnormal thinking, fast or irregular heartbeat and sweating. If so consult with your doctor.

Patient may develop with increased risk of involuntary movements; if so consult with your doctor.

It may develop increased risk of suicidal thoughts in children and teenagers; watch them carefully.

Avoid exposure to sunlight; otherwise it may cause sunburn.

It may cause heatstroke, protect from hot weather.

Contraindicated in patients with concurrent treatment with MAOIs, recent heart attack, heart diseases, severe liver disease and hypersensitivity.

Drug Interaction: Paralytic ileus may occur in patients taking tricyclic antidepressants in combination with anticholinergic drugs. Amoxapine may enhance the response to alcohol and the effects of barbiturates and other CNS depressants. Serum levels of several tricyclic antidepressants have been reported to be significantly increased when cimetidine is administered concurrently. Although such an interaction has not been reported to date with amoxapine, specific interaction studies have not been done, and the possibility should be considered.

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