Drug ID: 1d00000096
Drug Name: Amoxicillin
Generic Names: Bromoxy | Bromolin D (125mg) | Amov 625 (alu alu) | RTMox | Amoxipen | Trimox | Otymox | Tynimox -BR | Moxybexine | Vemoxin -D | Moxydil | Stamox B.R. | Optimox | Moxybexin (500mg) | Flemiklox -DX CAPS | Novamox Rediuse | Mucobron (30 ml) | Amimox -DC | Flemiclav - LB kid tab | Optimox | Mox | RTMox Kid | Pulmoxyl -AX | Sumox Plus | Trimox BX | Winclox Kid | Oxylac | Symoxyl - BR 500 | Clos -DX | Lizamox D | Amoxil | trimox | Moxatag | Wymox | Amoxil Pediatric Drops | trimox Pediatric Drops | More
Legal Status: Non Opioid Prescription only drug
Indication for Mother: Category B
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
Recommended Dose: Adult- The recommended dose range is 0.25 to 3gm.
Child- The recommended dose is 25 mg/kg/day in divided doses every 12 hours.
Recommended In: This medication is a penicillin-like , ?-lactam antibiotic. It is used to treat bacterial infections caused by susceptible microorganisms. It prevents the bacterial growth and is used in the treatment of a number of infections such as pneumonia, bronchitis, gonorrhea, and infections of the ears, nose, throat, urinary tract, and skin.
Directions For Use: Amoxicillin comes as a tablet, capsule, chewable tablet, syrup and pediatric drops to take by mouth. It is usually taken every 12 hours (twice a day) or every 8 hours (three times a day) with or without food. It is recommended that at least 10 days' treatment for any infection caused by Streptococcus pyogenes to prevent the occurrence of acute rheumatic fever.
Storage: apsules and dry powders should be stored at or below 20 C (68 F) and chewable tablets should be stored at room temperature (20-25°C), and in an airtight container. Keep away from children.
Dosage Forms: Tablet | Capsule | Chewable tablet | Syrup | Pediatric drops
Side Effects: Body as a whole - Fungal infections, severe allergic reactions, joint pain, or general ill feeling, severe tingling, sleeplessness, numbness and pain.
Gastrointestinal - Nausea, vomiting, diarrhea, antibiotic-associated colitis, black hairy tongue and intestinal bleeding.
Hypersensitivity - Anaphylactic shock, redness of skin, skin inflammation, hives, inflammation of blood vessels, itching, severe blistering and peeling.
Liver - Jaundice and liver inflammation.
Genitourinary - Crystals in urine, dark colored urine and vaginal itching or discharge.
Blood - Anemia, decrease in white blood cells, platelets, increase in eosinophils and bruising.
Central Nervous System - Reversible hyperactivity, agitation, anxiety, sleeplessness, confusion, convulsions, behavioral changes and dizziness.
Miscellaneous - Tooth discoloration, hear burn, white patches or sores inside mouth or on lips, easy bruising and bleeding.
In Case of Overdose: In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures as required. Crystalluria, in some cases leading to renal failure, has also been reported after amoxicillin overdosage in adult and pediatric patients. In case of overdosage, adequate fluid intake and diuresis should be maintained to reduce the risk of amoxicillin crystalluria.
Renal impairment appears to be reversible with cessation of drug administration. High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of amoxicillin. Amoxicillin may be removed from circulation by hemodialysis.
Avoid If: Caution should be exercised in patients with history of kidney disease, allergies, asthma, hay fever, hives, any allergy to any other penicillin antibiotic/cephalosporins, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
It may cause dizziness, do not drive a car or operate machinery while taking this medication.
Take full course of treatment.
Avoid long-term use of this medication; otherwise it may cause secondary infection.
Patient may experience stomach pain, severe diarrhea, blood in stool; if it so consult with your doctor.
Monitor liver function, kidney function and complete blood cell counts regularly while taking this medication.
Amoxicillin can make birth control pills less effective, therefore using a non-hormone method of birth control is recommended while on amoxicillin.
Avoid excess dosage.
Shake the liquid and pediatric drops well before each use to mix the medication evenly.
The chewable tablets should be crushed or chewed thoroughly before they are swallowed.
Patients with phenylketonuria, should be cautious while taking chewable form os amoxicillin as it may contain phenylalanine.
Drug Interaction: Probenecid
Probenecid decreases the renal tubular secretion of amoxicillin. Concurrent use of amoxicillin and probenecid may result in increased and prolonged blood levels of amoxicillin.
Abnormal prolongation of prothrombin time (increased international normalized ratio [INR]) has been reported in patients receiving amoxicillin and oral anticoagulants. Appropriate monitoring should be undertaken when anticoagulants are prescribed concurrently. Adjustments in the dose of oral anticoagulants may be necessary to maintain the desired level of anticoagulation.
The concurrent administration of allopurinol and amoxicillin increases the incidence of rashes in patients receiving both drugs as compared to patients receiving amoxicillin alone. It is not known whether this potentiation of amoxicillin rashes is due to allopurinol or the hyperuricemia present in these patients.
amoxicillin may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin. This has been demonstrated in vitro ; however, the clinical significance of this interaction is not well documented.