Drug ID: 1d00000107
Drug Name: Anthrax Vaccine Adsorbed
Generic Names: Biothrax
Category: Immunizing Agents
Legal Status: Non Opioid Prescription only drug
Indication for Mother: Category D
There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Recommended Dose: Adults- 0.5 mL as 5 intramuscular doses at day 0, week 4, then 6, 12, and 18 months.
Yearly booster injections of 0.5 mL are recommended for those who remain at risk.
Recommended In: This medication is an active immunization agent for the prevention of disease caused by Bacillus anthracis, in persons between 18 and 65 years of age whose occupation or other activities place them at high risk of exposure.
Directions For Use: It comes as a solution for injection, to be administered by a healthcare provider into the large muscle.
Storage: Store at 2°C to 8°C (36°F to 46°F). Do not freeze.
Dosage Forms: Intramuscular Injection
Side Effects: Most Common - Injection site tenderness, pain, warmth, muscle pain, arm motion limitation, fatigue and headache.
Central Nervous System - Tingling, tremor, nerve disease, dizziness, seizures, tremors, aseptic meningitis, encephalitis, transverse myelitis, cerebrovascular accident, facial palsy, hearing and visual disorders, Guillain-Barre Syndrome, and multiple sclerosis have been reported rarely; however, causality has not been established.
Skin - Itching, rash, hair loss, subcutaneous nodule, induration, and local pruritus.
Eye and ENT - Throat pain.
Gastrointestinal - Nausea, anorexia, diarrhea.
Hypersensitivity - Angioedema, rash, hives, itching, redness of the skin, and Stevens-Johnson syndrome.
Musculoskeletal - Back pain, neck pain, joint sprain, rigors, joint pain, damaged skeletal muscle.
Respiratory - Upper respiratory tract infection, transient respiratory difficulty.
Miscellaneous - Painful menstrual cycle, fever, chills, and influenza-like illness.
In Case of Overdose: No information available yet.
Avoid If: Caution needed for elderly, children, pregnant and breastfeeding women. Select a different injection site for each sequential injection of this vaccine.
BioThrax may be administered by the subcutaneous route for the persons with coagulation disorders.
Drug Interaction: Immunosuppressive therapies, including chemotherapy, corticosteroids (used in high-doses longer than 2-weeks), and radiation therapy may reduce the response of anthrax vaccine adsorbed emergent biosolutions.
No prospective, controlled clinical studies to assess the concomitant administration of anthrax vaccine adsorbed emergent biosolutions with other vaccines have been performed.