Drug ID: 1d00000108
Drug Name: Antihemophiliac factor
Generic Names: Fanhdi | Haemoctin Sdh Factor Viii | Hemofil-M | Monoclate-P | Advate | Xyntha | Helixate NexGen | Helixate FS | Bioclate | Kogenate FS | Recombinate | ReFacto | Wilate | Alphanate | Hemofil M Method M Monoclonal Purified | Humate-P | Koate-DVI | Monarc-M Method M Monoclonal Purified | Monoclate-P
Legal Status: Non Opioid Prescription only drug
Indication for Mother: Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Recommended Dose: The recommended dose is 5 –10 U/kg, repeated 6 to 12 hourly.
Recommended In: This medication is an essential blood-clotting factor, prescribed for controlling and preventing bleeding episodes in people with low levels of factor VIII (hemophilia A) and AHG deficiency. This product contains a man-made form of factor VIII, also called antihemophilic factor. This temporarily replaces the missing factor VIII, a protein (clotting factor) that is normally in the blood, so that the blood can clot and the bleeding can stop.
Directions For Use: It comes as a solution for injection to be administered by a healthcare provider into the vein. Warm diluent (Sterile Water for Injection, USP) and concentrate (Alphanate (antihemophilic factor) ) to at least room temperature (but not above 37 °C).
Storage: Store it in refrigerator (2 to 8°C), do not freeze it. May be stored at room temperature not to exceed 30 °C for up to 2 months.
Dosage Forms: Reconstituted powder for IV injection
Side Effects: Central Nervous System - Dizziness and headache.
Skin - Itching, flushing of face, hives, swelling of face, lips, tongue, or throat, burning/redness/irritation at the injection site and unusual bruising or bleeding.
Gastrointestinal - Stomach upset, stomach pain, loss of appetite, nausea, vomiting and sore throat.
Miscellaneous - Fever, chills, difficulty in breathing, fast heart beat and chest tightness.
In Case of Overdose: No symptoms of overdose with Antihemophiliac factor have been reported.
Avoid If: Caution needed in pregnant and breastfeeding women.
This medication should not be used to treat von Willebrand disease.
It may cause dizziness, do not drive a car or operate machinery while taking this medication.
Avoid excess dosage. Should not be administered at a rate exceeding 10 mL/minute. Rapid administration of a Factor VIII concentrate may result in vasomotor reactions.
Drug Interaction: There are no known drug interactions reported with Antihemophiliac factor. Drug interaction studies have not been performed.