Drug ID: 1d00000123
Drug Name: Artemether
Generic Names: Neomether (80mg) | Lumether Forte | Articom | Coartrin | Stanther | P Cidal Tab | Sunther (2ml) | Falcirid | Falciz (2ml) | Fimal (150mg) | Azfalcy (150mg) | Falcydol | Alfadin 150 | Larither (1 ml) | Alpharid | Falsitis (2ml) | Maliago | Asth | RTM Forte | Lumerax Syr | Lumether | Nomal -AR | Malin Art | Colther | Lumether (30 ml) | Falcide | R T Ther | Laristar Kid | AB -ther | Malialoc | Coartem | More
Category: Anti- Malarials
Legal Status: Non Opioid Prescription only drug
Indication for Mother: Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Recommended Dose: Adult dose- 80mg twice a day one day 1,followed by 80mg once a day for 4 days.Max dose-480mg.
Children- 1.6mg/kg twice a day on day 1,follwed by same dose once daily for 5 days.Max dose-9.6mg/kg A 3 day regime is also used alternatively.
Recommended In: This medication is a potent and quick acting antimalarial agent,used for treating chloroquine resistant falciparum malaria,including cerebral malaria.
Directions For Use: It comes as a solution for injection, to be administered by a healthcare provider into a large muscle.
Storage: Store it in refrigerator.
Dosage Forms: Intramuscular Injection
Side Effects: Cough, diarrhea, dizziness, fatigue, headache, joint and muscle pain and stiffness, loss of appetite, nausea, stomach pain, tiredness, trouble in sleeping, vomiting, and weakness.
In Case of Overdose: There is no information on overdoses of Artemether higher than the doses recommended for treatment.
In cases of suspected overdosage, symptomatic and supportive therapy, which would include ECG and blood electrolyte monitoring, should be given as appropriate.
Avoid If: Contraindicated in patients with hypersensitivity.
Caution should be exercised in patients with history of liver or kidney disease, heart problem, infection, mental illness, HIV, any allergy, who are taking other medications.
It may cause dizziness, do not drive a car or operate machinery while taking this medication.
Drug Interaction: Rifampin
Concomitant use of strong inducers of CYP3A4 such as rifampin, carbamazepine, phenytoin and St. John's wort is contraindicated with Artemether.
Both artemether and lumefantrine are metabolized by CYP3A4. Antiretroviral drugs, such as protease inhibitors and non-nucleoside reverse transcriptase inhibitors, are known to have variable patterns of inhibition, induction or competition for CYP3A4. Therefore, the effects of antiretroviral drugs on the exposure to artemether, DHA, and lumefantrine are also variable. Artemether should be used cautiously in patients on antiretroviral drugs because decreased artemether, DHA, and/or lumefantrine concentrations may result in a decrease of antimalarial efficacy of Artemether, and increased lumefantrine concentrations may cause QT prolongation.
In vitro, the metabolism of ethinyl estradiol and levonorgestrel was not induced by artemether, DHA, or lumefantrine. However, artemether has been reported to weakly induce, in humans, the activity of CYP2C19, CYP2B6, and CYP3A. Therefore, Artemether may potentially reduce the effectiveness of hormonal contraceptives. Patients using oral, transdermal patch, or other systemic hormonal contraceptives should be advised to use an additional non-hormonal method of birth control.
Lumefantrine inhibits CYP2D6 in vitro. Administration of Artemether with drugs that are metabolized by CYP2D6 may significantly increase plasma concentrations of the co-administered drug and increase the risk of adverse effects. Many of the drugs metabolized by CYP2D6 can prolong the QT interval and should not be administered with Artemether due to the potential additive effect on the QT interval (e.g., flecainide, imipramine, amitriptyline, clomipramine).
Interaction with Drugs that are Known to Prolong the QT Interval
Artemether is to be used with caution when co-administered with drugs that may cause prolonged QT interval such as antiarrhythmics of classes IA and III, neuroleptics and antidepressant agents, certain antibiotics including some agents of the following classes: macrolides, fluoroquinolones, imidazole, and triazole antifungal agents.