Resource id #3DrugId:1d00000130resource(4) of type (mysql result) Drug Search

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Drug ID: 1d00000130

Drug Name: Astemizole

Generic Names: Acemiz (60 ml) | Stemiz | Astemizole | Stemiz | Minastem | Stemiz (50 ml) | Astizole | Alestol | Perione | Astelong (60 ml) | Histeese | Histeese (50 ml) | Stemiz (30 ml) | Alerzole | Acemiz | Histeese Tab | Astelong | Alerzole (60 ml) | Rhinigo | Acipax | Hismanal

Category: Antihistamines

Legal Status: Non Opioid Prescription only drug

OTC: No

Indication for Mother: Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Recommended Dose: Adult: The recommended dose is 10 mg once daily.

Recommended In: This medication is an antihistamine, prescribed for allergic rhinitis and chronic idiopathic urticaria.

Directions For Use: It comes as a tablet to take by mouth, on an empty stomach.

Storage: Store it at room temperature (15- 30C).

Dosage Forms: Tablet

Side Effects: Severe Effects - Abnormal heart rhythm.

Most Common - Palpitations, low blood pressure and dizziness.

Central Nervous System - Drowsiness, headache, fatigue, increased appetite and weight and nervousness.

Gastrointestinal System - Nausea, diarrhea and abdominal pain.

Eye and ENT - Dry mouth, inflammation of pharynx and eye.

Other - Joint pain.

In Case of Overdose: In the event of overdosage, supportive measures including gastric lavage and emesis should be employed. Substantial overdoses of Astemizole can cause death, cardiac arrest, QT prolongation, cardiac arrest, torsades de pointes, and other ventricular arrhythmias.

Seizures and syncope have also been reported with overdose and may be associated with a cardiac event.

Overdose patients should be carefully monitored as long as the QT interval is prolonged or arrhythmias are present. In some cases, this has been up to six days. In overdose cases in which ventricular arrhythmias are associated with significant QT prolongation, treatment with antiarrhythmics known to prolong QT intervals is not recommended.

Astemizole does not appear to be dialyzable.

Avoid If: Avoid excess dosage; otherwise it may cause severe heart problem.

Caution should be exercised in patients with history of prostate enlargement, urinary retention, increased eye pressure, intestinal obstruction, liver diseases, epilepsy, children, elderly, during pregnancy and breastfeeding.

It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.

Contraindicated in patients with bruising.

Drug Interaction: Ketoconazole/Itraconazole: Concomitant administration of ketoconazole tablets or itraconazole with astemizole is contraindicated. Due to the chemical similarity of fluconazole, metronidazole, and miconazole IV to ketoconazole, concomitant use of these products is not recommended.

Macrolides (Including Erythromycin): Concomitant administration of erythromycin with astemizole is contraindicated. Concomitant administration of astemizole with other macrolide antibiotics, including troleandomycin, azithromycin, and clarithromycin, is not recommended.



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