Drug ID: 1d00000146
Drug Name: Azelastine
Generic Names: Azelast Nasal | Azelast | Azelast Nasal | Optihist -AZ Eye | Duonase | Optihist -AZ Eye | Azenate Nasal | Azenate Nasal | Duonase | Oculast | Oculast | Azep Nasal | Azelast | Azep Nasal | Astelin | Astepro | Optivar
Category: Nasal Medications
Legal Status: Non Opioid Prescription only drug
Indication for Mother: Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Recommended Dose: Adult: The recommended dose is two sprays per nostril twice daily.
Child: The recommended dose is one spray per nostril twice daily.
Recommended In: This medication is a selective histamine antagonist, prescribed in treating allergic rhinitis. It blocks the histamine action, which reduces allergy symptoms.
Directions For Use: It comes as a nasal spray.
Storage: Store it at controlled room temperature 20°- 25°C.
Dosage Forms: Nasal Spray
Side Effects: Most Common- Bitter taste, headache, drowsiness, nasal burning, inflammation of pharynx/nose, dry mouth, sneezing, nausea, fatigue, dizziness, nosebleed and increased weight.
Body as Whole- Allergic reaction, back pain, viral infection, discomfort or uneasiness, pain in extremities, abdominal pain and fever.
Heart - Flushing, high blood pressure and fast heart rate.
Skin- Contact dermatitis, inflammation, hair follicle infection, skin infection and skin laceration.
Gastrointestinal- Constipation, inflammation of stomach/tongue/intestine, ulcer, vomiting, increased SGPT, diarrhea and toothache.
Metabolic- Increased appetite.
Musculoskeletal- Muscle/joint pain, jawbone dislocation and joint inflammation.
Central Nervous System- Hyperactivity and fainting.
Psychological- Anxiety, depersonalization, depression, nervousness, sleep disorder and abnormal thinking.
Respiratory- Asthma, coughing, throat burning, inflammation of larynx/bronchus/sinus, dry throat, shortness of breath, nasal congestion, nasal dryness and post nasal drip.
Eye and ENT- Eye inflammation, eye pain, watery eyes, nasal sore and loss of taste.
Genitourinary - Presence of albumin in urine, breast pain, absence of menstrual period, blood in urine and increased urinary frequency.
In Case of Overdose: There is no known antidote to Azelastine. Oral ingestion of antihistamines has the potential to cause serious adverse effects in young children.
Responses seen prior to death were tremor, convulsions, decreased muscle tone, and salivation.
Avoid If: It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.
Avoid alcoholic beverages.
Caution needed for pregnant and breastfeeding women.
Drug Interaction: Concurrent use of Astelin Nasal Spray with alcohol or other CNS depressants should be avoided because additional reductions in alertness and additional impairment of CNS performance may occur.
Cimetidine increased the mean Cmax and AUC of orally administered azelastine hydrochloride by approximately 65%. Ketoconazole interfered with the measurement of azelastine plasma concentrations; however, no effects on QTc were observed.