Drug ID: 2d00000003
Drug Name: Baclofen
Generic Names: Liofen | Lioresal Intrathecal (0.05 mg) | Lioresal | Lioresal (10 mg) | Liofen XL (10 mg) | Liofen (5 mg) | Bacmax (10 mg) | Baclof OD (20 mg) | Riclofen | Tefsole (10 mg) (Neon) | Spinofen (25 mg) | Liofen XL (20 mg) | Lioresal (25 mg) | Spinofen (10 mg) | Riclofen (25 mg) | Liofen | Chinofen (10 mg) | Liofen (0.05 mg) | Lioresal | Liofen | Riclofen | Lioresal Intrathecal (10 mg) | Baclof (10 mg) | Liofen XL (30 mg) | Liofen | Tefsole | Spinospas (10 mg) | Liofen (25 mg) | Liofen Inj (10 mg) | Liofen XL (40 mg) | Lioresal Intrathecal | More
Category: Skeletal Muscle Relaxants
Legal Status: Non Opioid Prescription only drug
Indication for Mother: Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Recommended Dose: The recommended dose is 5 mg three times a day for 3 days 10 mg three times a day for 3 days 15 mg three times a day for 3 days 20 mg three times a day for 3 days. It may be increased if needed.
Recommended In: This medication is a derivative of gamma-aminobutyric acid (GABA), prescribed for severe chronic spasticity. It also relieves pain and improves muscle movement.
Directions For Use: It comes as a tablet to take by mouth, with food.
Storage: Store it at room temperature (25°C), and in an airtight container.
Dosage Forms: Tablet | Intrathecal Injection
Side Effects: Most Common - Drowsiness.
Central Nervous System - Sedation, unsteadiness, dizziness, headache, confusion and hallucinations.
Gastrointestinal - Stomach upset, nausea, constipation, dry mouth, loss of appetite, taste disorder, abdominal pain, vomiting and diarrhea.
Heart - Low blood pressure, difficulty in breathing, palpitation, chest pain and fainting.
Genitourinary - Urinary frequency and bedwetting.
Miscellaneous - Rash, itching, ankle swelling, excessive perspiration, weight gain and nasal congestion.
In Case of Overdose: Special attention must be given to recognizing the signs and symptoms of overdosage, especially during the initial screening and dose-titration phase of treatment, but also during re-introduction of baclofen after a period of interruption in therapy.
Symptoms of intrathecal baclofen Overdose
Drowsiness, lightheadedness, dizziness, somnolence, respiratory depression, seizures, rostral progression of hypotonia and loss of consciousness progressing to coma of up to 72 hours duration. In most cases reported, coma was reversible without sequelae after drug was discontinued. Symptoms of intrathecal baclofen overdose were reported in a sensitive adult patient after receiving a 25 mcg intrathecal bolus.
Treatment Suggestions for Overdose
There is no specific antidote for treating overdoses of baclofen; however, the following steps should ordinarily be undertaken:
Residual intrathecal baclofen solution should be removed from the pump as soon as possible.
Patients with respiratory depression should be intubated if necessary, until the drug is eliminated.
Anecdotal reports suggest that intravenous physostigmine may reverse central side effects, notably drowsiness and respiratory depression. Caution in administering physostigmine is advised, however, because its use has been associated with the induction of seizures and bradycardia.
Physostigmine Doses for Adult Patients
Administer 2 mg of physostigmine intramuscularly or intravenously at a slow controlled rate of no more than 1 mg per minute. Dosage may be repeated if life-threatening signs, such as arrhythmia, convulsions or coma occur.
Physostigmine Doses for Pediatric Patients
Administer 0.02 mg/kg physostigmine intramuscularly or intravenously, do not give more than 0.5 mg per minute. The dosage may be repeated at 5 to 10 minute intervals until a therapeutic effect is obtained or a maximum dose of 2 mg is attained
Physostigmine may not be effective in reversing large overdoses and patients may need to be maintained with respiratory support.
Avoid If: Caution should be exercised in patients with history of kidney disease, epilepsy, ulcers, stroke, rheumatic disease, cerebral palsy, Parkinson's disease, psychiatric condition, any allergy, who are taking other medications, elderly, children, pregnancy and breastfeeding.
It may cause drowsiness, do not drive a car or operate machinery while taking this medication.
Avoid alcohol consumption.
Avoid excess dosage.
Contraindicated in patients with peptic ulcer and hypersensitivity.
Drug Interaction: There is inadequate systematic experience with the use of intrathecal baclofen in combination with other medications to predict specific drug-drug interactions. Interactions attributed to the combined use of intrathecal baclofen and epidural morphine include hypotension and dyspnea.