Resource id #3DrugId:2d00000054resource(4) of type (mysql result) Drug Search

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Drug ID: 2d00000054

Drug Name: Bosutinib

Generic Names: Bosulif

Category: Kinase Inhibitor

Legal Status: Non Opioid Prescription only drug


Indication for Mother: Category D
There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Recommended Dose: The recommended dose is 500mg once daily.

Recommended In: This medication is a kinase inhibitor, prescribed for chronic myelogenous leukemia (CML).

Directions For Use: It comes as a tablet to take by mouth, with food.

Storage: Store at 20C to 25C.

Dosage Forms: Tablet

Side Effects: Serious Effects - Liver toxicity, fluid retention, gastrointestinal toxicity, bone marrow suppression.

Most Common - Diarrhea, nausea, decrease in platelets, vomiting, abdominal pain, rash, anemia, pyrexia, and fatigue.

Blood and Lymphatic System Disorders - Anemia, decrease in white blood cells.

General - Fatigue, fever, fluid retention, weakness.

Infections - Respiratory tract infection, inflammation of the nasopharynx.

Metabolic - Decreased appetite, increase in liver enzymes.

Musculoskeletal - Joint pain, back pain.

Central Nervous System - Headache, dizziness.

Respiratory - Difficulty in breathing, cough.

In Case of Overdose: Patients who take an overdose of Bosutinib should be observed and given appropriate supportive treatment.

Avoid If: Caution should be exercised in patients with history of liver or heart disease, who are taking other medications, any allergy, during pregnancy and breastfeeding.

Monitor liver function regularly while taking this medication.

Drug Interaction: Some products that may interact with this drug include: drugs that reduce stomach acid (for example, antacids, H2 blockers such as famotidine/ranitidine, proton pump inhibitors such as omeprazole).

Other medications can affect the removal of bosutinib from your body, which may affect how bosutinib works. Examples include azole antifungals (such as ketoconazole, itraconazole), boceprevir, macrolide antibiotics (such as clarithromycin), nefazodone, HIV protease inhibitors (such as indinavir, nelfinavir, ritonavir), rifamycins (such as rifabutin), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenytoin), telaprevir, telithromycin, among others.

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