Resource id #3DrugId:2d00000055resource(4) of type (mysql result) Drug Search

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Drug ID: 2d00000055

Drug Name: Botulinum Toxin Type A

Generic Names: Botox

Category: Musculoskeletal Agents

Legal Status: Non Opioid Prescription only drug


Indication for Mother: Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Recommended Dose: Inject 50 units (2 mL of reconstituted solution) intradermally into defined hyperhidrotic area in 0.1 to 0.2 mL aliquots to each axilla evenly distributed in multiple sites (10 to 15) approximately 1 to 2 cm apart. Administer repeat injections when clinical effect of previous injection diminishes.

Recommended In: This medication is an injectable neuro-toxin, indicated for spasms (involuntary muscle contractions) of neck, upper arm, eye or eyelid, as well as increased sweating in the armpits.

Directions For Use: This injection comes as a powder to be mixed with a liquid and injected into the muscle or into the skin by healthcare provider.

Storage: Botox is usually handled and stored by a health care provider.

Dosage Forms: Reconstituted vial for Intramuscular injection

Side Effects: Central Nervous System- Headache, discomfort, unusual tiredness and fear.

Miscellaneous- Body aches or pain, chills, cough, fever, sneezing, joint pain and itching skin.

In Case of Overdose: Symptoms of overdose are likely not to be present immediately following injection. Should accidental injection or oral ingestion occur or overdose be suspected, the person should be medically supervised for several weeks for signs and symptoms of systemic muscular weakness which could be local, or distant from the site of injection.

If the musculature of the oropharynx and esophagus are affected, aspiration may occur which may lead to development of aspiration pneumonia. If the respiratory muscles become paralyzed or sufficiently weakened, intubation and assisted respiration may be necessary until recovery takes place. Supportive care could involve the need for a tracheostomy and/or prolonged mechanical ventilation, in addition to other general supportive care.

In the event of overdose, antitoxin raised against botulinum toxin is available from the Centers for Disease Control and Prevention (CDC) in Atlanta, GA. However, the antitoxin will not reverse any botulinum toxin-induced effects already apparent by the time of antitoxin administration.

Avoid If: Hypersensitivity to any ingredient in the formulations.

Use same brand of botox.

Caution should be exercised in patients with history of eye or face surgery, bleeding problems, seizures, hyperthyroidism, heart disease.

It may cause loss of strength or muscle weakness. Do not drive a car, or operate machinery, or other dangerous activities while taking this medication.

Caution needed in patients who are taking anticoagulants or with bleeding disorders.

Drug Interaction: Aminoglycosides and Other Agents Interfering with Neuromuscular Transmission

Co-administration of Botulinum and aminoglycosides or other agents interfering with neuromuscular transmission (e.g., curare-like compounds) should only be performed with caution as the effect of the toxin may be potentiated.

Anticholinergic Drugs

Use of anticholinergic drugs after administration of Botulinum may potentiate systemic anticholinergic effects.

Other Botulinum Neurotoxin Products

The effect of administering different botulinum neurotoxin products at the same time or within several months of each other is unknown. Excessive neuromuscular weakness may be exacerbated by administration of another botulinum toxin prior to the resolution of the effects of a previously administered botulinum toxin.

Muscle Relaxants

Excessive weakness may also be exaggerated by administration of a muscle relaxant before or after administration of Botulinum.

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